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This inherent structure of the bases leads to purine and pyrimidine difference. Do You Know? The identification of pyrimidine compounds took a long time. Even though its isolation took place somewhere within and , the recognition of its structures did not come through till Function of Purine and Pyrimidine Bases. Purine Catabolism. Owing to the end-product of purine catabolism being uric acid, it has a significant role to play in our body.
The urate oxidase enzyme is not present in the human body, and from uric acid, urate is created. Formation of uric acid takes place in the liver and subsequently discharged with urine through the kidney. In the human body, monosodium salt and un-dissociated uric acid are least soluble. Such nature usually does not cause any problem in the human body unless urine has very high acidic content.
Concentration of urate eventually causes the development of gout. Both bases are sources of energy. The process in which these two compounds form hydrogen is called base pairing. Purines and Pyrimidines. A purine is known for being a heterocyclic aromatic organic compound.
It is made up of a pyrimidine ring that is fused to an imidazole ring. It can be created artificially through a Traube purine synthesis.
In , this compound was coined by a German chemist Emil Fischer. It is said that purines are biologically synthesized as nucleosides. They are found in high concentrations in meat products, especially inside livers and kidneys.
Examples of purines are sweetbreads, anchovies, mackerel, scallops, beer from the yeast, and gravy. On the other hand, similar to the purine, a pyrimidine is an aromatic heterocyclic organic compound, but it is made up of only one carbon ring.
Its rings are also components of several larger compounds, like thiamine and some synthetic barbiturates.
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